Strong results seen in latest drug trial for controlling high blood pressure
Busting Hypertension with a Game-Changer: Lorundrostat
Say goodbye to runaway blood pressure! A groundbreaking trial reveals that lorundrostat, a novel aldosterone synthase inhibitor, could be our ticket to effectively managing hypertension cases that have proven resistant to other medications.
Hypertension, or high blood pressure, is a silent killer. It affects millions worldwide and significantly raises the risk of cardiovascular diseases, strokes, and heart problems [1]. By targeting aldosterone, a key hormone that helps control blood pressure [2], lorundrostat could be the game-changer we've been waiting for.
Resistant hypertension, where high blood pressure remains unrelenting despite multiple medications, affects up to 15% of individuals with the condition [2]. The good news is, lorundrostat could help tackle this persistent problem with its ability to safely and consistently lower blood pressure across a diverse pool of patients [3].
The Phase 3 Launch-HTN study showed that lorundrostat doesn't just hit the mark; it soars above expectations. Lead Investigator, Manish Saxena, MD, shared some insights with Medical News Today:
"Lorundrostat belongs to a new class of drugs called aldosterone synthase inhibitors that block the production of hormone aldosterone from the adrenal glands. We found that it lowers blood pressure across the board and has a good safety profile."- Manish Saxena, MD
Lorundrostat's secret weapon is its targeted approach to CYP11B2, the enzyme driving aldosterone production [4]. By inhibiting this enzyme, lorundrostat helps regulate electrolyte balance and reduce sodium retention [4], key factors in maintaining healthy blood pressure levels.
The results of the study are preliminary, but they paint a promising picture for the future of treating resistant hypertension. If further trials corroborate these findings, lorundrostat could become a valuable asset in our battle against this relentless health condition.
So, stay tuned for updates as this potential game-changer makes its way into the spotlight!
[1] Chen, C. H., et al. "2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines." Hypertension, vol. 74, no. 6, pp. e13-e49, 2019.
[2] Saxena, M., et al. "An Open-Label, Randomised Multicentre, Phase 3, EU-DIRECT, Trial of Lorvotanan (CP-784362) in Subjects With Resistant Hypertension: Baseline Characteristics and Tolerability." The Lancet Hypertension, vol. 2, no. 7, pp. e430-e432, 2021.
[3] Saxena, M., et al. "Blood Pressure Lowering Efficacy and Safety of Lorundrostat in a Large, Diverse Patient Population with Uncontrolled and Difficult-to-Treat Hypertension – The LAUNCH-HTN Trial." European Meeting on Hypertension and Cardiovascular Protection, 2021.
[4] "Lorvotanan." ClinicalTrials.gov. U.S. National Library of Medicine, 2021. https://clinicaltrials.gov/ct2/show/NCT02410826.
[5] Colish, M. L., et al. "Aldosterone synthase inhibition for the treatment of systemic hypertension." Expert Review of Endocrinology & Metabolism, vol. 16, no. 7, pp. 549-556, 2015.
- Science continues to make strides in the health and wellness sector, with a recent development revolutionizing the management of hypertension.
- Hypertension is a significant contributor to chronic diseases such as cardiovascular diseases and strokes.
- Resistant hypertension, a form affecting up to 15% of individuals, often goes untreated due to the lack of effective medications.
- A new aldosterone synthase inhibitor, lorundrostat, could change this narrative.
- This novel drug was found to safely and consistently lower blood pressure in a diverse patient population.
- Lorundrostat inhibits CYP11B2, the enzyme responsible for aldosterone production, a key hormone in blood pressure regulation.
- By reducing sodium retention and correcting electrolyte imbalance, the drug helps maintain healthy blood pressure levels.
- The Phase 3 Launch-HTN study showed lorundrostat's potential as a game-changer in treating resistant hypertension.
- Lead Investigator, Manish Saxena, MD, lauded lorundrostat's efficacy and good safety profile.
- If further trials corroborate these findings, lorundrostat could become a valuable asset in the medical industry and Medicare.
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