Asthma Symptoms, Treatment Options, and Further Information (Regarding Mild, Persistent Asthma)
Asthma, a common inflammatory condition that affects a person's airways, can be managed effectively, especially when it comes to mild persistent asthma. This form of asthma, which affects up to 50% of all people with the condition, is characterised by symptoms occurring at least twice weekly but not daily, nighttime flare-ups happening at least twice per month but less than once a week, and lung function being at least 80% of typical lung function.
The diagnosis of asthma typically involves a doctor asking about symptoms, examining the lower respiratory tract, measuring lung function, and assessing Peak Expiratory Flow (PEF) variability over an extended period. PEF measures the rate at which a person can expel air from their lungs over time and can help the doctor assess the severity and persistence of a person's asthma.
The treatment for mild persistent asthma primarily includes the daily use of low-dose inhaled corticosteroids (ICS) to reduce airway inflammation and prevent symptoms. Common ICS medications include fluticasone (100-500 mcg twice daily) and budesonide (200-800 mcg twice daily). Alongside ICS, patients often use quick-relief inhalers, such as short-acting beta-agonists (SABAs), for immediate symptom relief during asthma attacks.
More recent guidelines, such as those from GINA (Global Initiative for Asthma), favour the use of low-dose ICS combined with formoterol (a long-acting beta-agonist) as both maintenance and reliever therapy (called anti-inflammatory reliever or AIR therapy). This approach reduces severe exacerbations with a simpler regimen.
If symptoms persist despite low-dose ICS, additional treatments might be considered, such as increasing ICS dose, adding leukotriene receptor antagonists (e.g., montelukast) to reduce inflammation, or using long-acting muscarinic antagonists (LAMA) for further symptom control.
It is important to note that the severity of asthma can change from mild to severe or severe to mild, and treatment plans should be personalised by healthcare providers based on symptom frequency, lung function, and patient response, with regular follow-up to monitor control and adjust therapy as needed.
In all cases, an individual who thinks they may have asthma should seek the advice of a medical health professional. If left untreated, asthma can be disruptive, and sometimes, dangerous.
| Treatment Option | Purpose | |-------------------------------------|----------------------------------| | Low-dose inhaled corticosteroids (ICS) | Long-term control, reduce airway inflammation | | Short-acting beta-agonists (SABA) | Quick relief during asthma attacks | | ICS + formoterol (AIR therapy) | Combined maintenance and reliever therapy | | Leukotriene receptor antagonists | Add-on anti-inflammatory treatment | | Long-acting muscarinic antagonists (LAMA) | Add-on symptom relief |
This combination approach helps maintain symptom control, reduce exacerbation risk, and improve quality of life in mild persistent asthma. ICS therapy works by reducing inflammation in the airways and is effective at preventing flare-ups. Common asthma triggers include dust, smoking, air pollution, coughing, exercise, animals, humidity, mold, cold air, cleaning products, strong odors, stress, and more.
References: [1] Global Initiative for Asthma (GINA). (2021). GINA 2021 Executive Summary. Retrieved from https://ginasthma.org/wp-content/uploads/2021/05/GINA-2021-Executive-Summary-English.pdf [2] National Heart, Lung, and Blood Institute. (2020). What Is Asthma? Retrieved from https://www.nhlbi.nih.gov/health-topics/asthma [3] American Academy of Allergy, Asthma & Immunology. (2021). Asthma. Retrieved from https://www.aaaai.org/conditions-and-treatments/library/asthma [4] British Lung Foundation. (2021). Asthma. Retrieved from https://www.blf.org.uk/support-for-you/lung-conditions/asthma [5] American College of Allergy, Asthma & Immunology. (2021). Asthma. Retrieved from https://acaai.org/asthma/overview
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